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When Haematopoiesis Goes Wrong Quiz

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Which statement best distinguishes leukaemia from lymphoma?

  1. A Leukaemia only affects lymphocytes, whereas lymphoma affects all blood cell lineages
  2. B Leukaemia primarily involves malignant cells in the bone marrow and blood, whereas lymphoma primarily involves lymph nodes and other tissues
  3. C Leukaemia is caused by platelet dysfunction, whereas lymphoma is caused by erythrocyte dysfunction
  4. D Leukaemia is always acute in onset, whereas lymphoma is always chronic
  5. E Leukaemia arises from mature blood cells, whereas lymphoma arises from immature precursor cells
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Answer: B. Leukaemia primarily involves malignant cells in the bone marrow and blood, whereas lymphoma primarily involves lymph nodes and other tissues

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See Leukaemia classification. Option B gives the usual anatomical distinction between leukaemia and lymphoma. Leukaemia predominantly involves marrow and blood, while lymphoma usually forms masses in lymph nodes or other tissues. Both are malignant disorders of blood-forming or immune cells, but their distribution changes how they present. Marrow involvement can disrupt normal cell production, causing anaemia, infections or bleeding. The boundary is not absolute: lymphoma can spread to marrow and blood, and some lymphoid cancers have both leukaemic and lymphomatous forms. Location is therefore a useful starting distinction rather than an infallible rule.

A is too restrictive because leukaemia can arise in myeloid or lymphoid cell lineages, while lymphoma is a lymphoid malignancy. D confuses distribution with pace: chronic leukaemias exist, and lymphomas range from slowly growing to aggressive. E cannot separate the diseases by maturity, since chronic leukaemias may have relatively mature malignant cells and lymphomas include mature-cell and precursor forms. C mistakes consequences for causes: anaemia and platelet abnormalities may follow marrow disease, but neither defines these cancers.

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More questions from this set. Start the quiz to answer them and see each explanation.

  1. 1

    Which statement best describes reactive thrombocytosis?

  2. 2

    A 22-year-old woman presents with recurrent infections, easy bruising and increasing fatigue over several months. Blood tests show low haemoglobin, low platelet count and low white cell count. A bone marrow biopsy demonstrates marked hypocellularity with few haematopoietic cells and no dysplastic changes or malignant infiltration. Which underlying mechanism best explains her condition?

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