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Tuberculosis Quiz
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Which symptom pattern is most characteristic of pulmonary tuberculosis at presentation?
- A Sudden onset pleuritic chest pain with acute breathlessness You picked ✕
- B Persistent chest pain without cough or systemic features You picked ✕
- C Gradual onset of cough with weight loss and fever You picked ✓
- D Isolated wheeze that improves with bronchodilators You picked ✕
- E High fever with rigors and rapid symptom resolution after antibiotics You picked ✕
Correct!
Incorrect
The answer is C: Gradual onset of cough with weight loss and fever
Explanation
Why C is correct
See Presentation. Option C is correct because pulmonary tuberculosis has a gradual onset, with constitutional symptoms (general symptoms of illness affecting the whole body) such as tiredness, weight loss and fever, often with sweats, together with a cough that may be dry or productive. Haemoptysis, which is coughing up blood, can occur because of the haemorrhage in the cavity of the lung, but it does not happen in every patient. There may be crackles on listening to the chest, but there may also be no abnormal signs, which is why a chest radiograph is essential in establishing the diagnosis. TB is more likely, and should therefore be considered, in people who were born outside the UK, have recently travelled to an area where TB is common, are immunocompromised, or have been in close contact with someone with TB. The slow, smouldering pattern reflects the chronic cell-mediated inflammation of the infection. A useful reminder is that TB is a slow burn, not a sudden event.
- Onset: gradual.
- General symptoms: tiredness, weight loss, fever and sweats.
- Cough: dry or productive, with haemoptysis in some patients.
- Risk factors: birth outside the UK, recent travel to a high-incidence area, immunocompromise or close contact with a case.
In a stem, look for the slow tempo and the whole-body symptoms to identify tuberculosis, and then look for the risk factors such as birth or travel in a high-incidence area, immunocompromise or close contact with a case.
Why the other options are incorrect
- A. Sudden onset pleuritic chest pain with acute breathlessness: Sudden pleuritic chest pain with acute breathlessness suggests an acute event, such as a pneumothorax or pulmonary embolism. Tuberculosis typically has a gradual onset instead. Your answer
- B. Persistent chest pain without cough or systemic features: Persistent chest pain without cough or systemic features does not fit tuberculosis, which usually causes tiredness, weight loss, fever and a cough. Your answer
- D. Isolated wheeze that improves with bronchodilators: An isolated wheeze that improves with bronchodilators points to reversible airway disease such as asthma. It is not the typical pattern of tuberculosis, which has systemic features. Your answer
- E. High fever with rigors and rapid symptom resolution after antibiotics: High fever with rigors that settles quickly after antibiotics suggests an acute bacterial infection. Tuberculosis has a gradual onset and does not clear with a short course of ordinary antibiotics. Your answer
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More questions from this set. Start the quiz to answer them and see each explanation.
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1
Which staining method is most appropriate for demonstrating acid-fast bacilli such as Mycobacterium tuberculosis in a clinical sample?
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2
A 22-year-old woman is taking standard first-line treatment for pulmonary tuberculosis. After several weeks she reports tingling and numbness in her feet. Which measure most directly prevents this adverse effect?
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